Host macrophage transcriptomic responses to M. Tuberculosis infection

Principal Investigator: John Howard White
Theme : Health
Competition : Genomics research in human health - general stream
Status : Completed
Start : Oct. 1, 2010
End: Sept. 30, 2013
Budget : $1,273,156.00



Tuberculosis has been resurgent recently, with ~9 million cases and 1.7 million deaths in 2004, and represents the leading cause of death from a curable disease. This upsurge is due in part to: the HIV epidemic, population migration and the emergent evolution of antibiotics-resistant bacteria. The pathogenic bacteria responsible for M. tuberculosis (Mtb) replicates within cells of the immune system called macrophages over a ~72h period, ultimately inducing cell death. There is broad evidence that vitamin D modulates macrophage responses to Mtb. Elevated levels of TB, particularly in vulnerable immigrant populations, have long been associated with vitamin D deficiency, suggesting that vitamin D supplementation may be of therapeutic benefit.


The goal of this project is to fully understand the host macrophage response to Mtb infection through the use of cutting-edge genomics techniques and the role of vitamin D in boosting the host response against infection using similar techniques. The results of this project will allow the discovery of new immunization approaches and therapies to fight tuberculosis.

 

Co-applicants:

Marcel Behr McGill University
Mathieu Blanchette McGill University
Maziar Divangahi McGill University
Suneil Malik Public Health Agency of Canada
Rob Sladek McGill University
Andrew F. Smith McGill University