Host macrophage transcriptomic responses to M. Tuberculosis infection

Principal Investigator: John Howard White
Theme : Health
Competition : Genomics research in human health - general stream
Status : Completed
Start : Oct. 1, 2010
End: Sept. 30, 2013
Budget : $1,273,156.00

Tuberculosis has been resurgent recently, with ~9 million cases and 1.7 million deaths in 2004, and represents the leading cause of death from a curable disease. This upsurge is due in part to: the HIV epidemic, population migration and the emergent evolution of antibiotics-resistant bacteria. The pathogenic bacteria responsible for M. tuberculosis (Mtb) replicates within cells of the immune system called macrophages over a ~72h period, ultimately inducing cell death. There is broad evidence that vitamin D modulates macrophage responses to Mtb. Elevated levels of TB, particularly in vulnerable immigrant populations, have long been associated with vitamin D deficiency, suggesting that vitamin D supplementation may be of therapeutic benefit.

The goal of this project is to fully understand the host macrophage response to Mtb infection through the use of cutting-edge genomics techniques and the role of vitamin D in boosting the host response against infection using similar techniques. The results of this project will allow the discovery of new immunization approaches and therapies to fight tuberculosis.



Marcel Behr McGill University
Mathieu Blanchette McGill University
Maziar Divangahi McGill University
Suneil Malik Public Health Agency of Canada
Rob Sladek McGill University
Andrew F. Smith McGill University