Guy Sauvageau

Affiliation : Université de Montréal
Organization : Institut de recherche en immunologie et en cancérologie (IRIC)
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About Guy Sauvageau

Dr. Guy Sauvageau is Chief Executive Officer and founding Scientific Director of the Institute for Research in Immunology and Cancer (IRIC) at Université de Montréal. He is a clinician-scientist specialized in oncology-hematology (Hôpital Maisonneuve-Rosemont) and the Scientific Director of the Leukemia Cell Bank of Québec. He also holds the Canada Research Chair in the Molecular Genetics of Stem Cells and is Professor of Medicine at the Université de Montréal.

His laboratory uses functional genomics approaches to study the molecular basis of stem cells self-renewal with special interest in chromatin modifying factors. Dr. Sauvageau’s work has led to ground-breaking discoveries in understanding the production of hematopoietic and leukemic stem cells.  With his research team, he identified the potential of the HOXB4 and Bmi1 genes which are instrumental in regulating the self-renewal of these cells and went on to develop recombinant proteins that led to the expansion of hematopoietic stem cells ex vivo. More recently, his team also developed small molecules inducing the expansion of hematopoietic stem cells ex vivo as well as novel genome-wide screen approaches that identified many new cellular regulators of hematopoietic stem cells. In the last few years, his team has led a large scale genomics project aimed at the identification of all genetic mutations associated with certain types of leukemia. This work has important clinical applications, currently under development.

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