Development of a predictive tool for micro and macrovascular complications in patients with Type 2 Diabetes

Principal Investigator: Pavel Hamet
Theme : Health
Competition : Genomics research in human health - translational stream
Status : Completed
Start : Oct. 1, 2010
End: Mar. 31, 2014
Budget : $2,000,000.00

Diabetes, an increasingly common condition, is associated with a significant risk of cardiovascular complications, such as heart attacks, strokes or renal insufficiency. Having a good assessment of such risk in a patient is critical information for the clinician, in order to guide life style recommendations and prescribe the best medications. Evidence shows that genetics plays an important role in the occurrence of such complications related to diabetes, but nowadays genetic information is not yet part of the routine assessment of the risk.

This project proposes to identify relevant genetic information (DNA and its alterations over time) and combine it with other characteristics of patients in the form of a tool, which will be made available to clinicians and their diabetic patients. The intent is to fine tune the set of useful genetic markers and then to combine them with the medical information currently used to assess the risk of complications. This project will contribute to the improvement of management care of diabetic patients while controlling the health care related cost of the complications of a disease that became a modern pandemic.



John Chalmers The George Institute for International Health
Ondrej Seda Université de Montréal
Michele Stanton-Jean Université de Montréal
Johanne Tremblay Université de Montréal
Mark Woodward The George Institute for International Health