Zoha Kibar


Affiliation : Université de Montréal
Organization : Centre hospitalier universitaire Sainte-Justine
E-mail : zoha.kibar@recherche-ste-justine.qc.ca



About Zoha Kibar


Zoha Kibar is a scholarship recipient Junior 1 who started her career at the Research Center of the Centre hospitalier universitaire Sainte-Justine in January 2007, as an assistant professor in the department of Obstetrics and Gynecology at the Université de Montréal. She finished her doctoral studies in Biology at McGill University in October 1999. She next conducted her postdoctoral studies at McGill University where she identified the gene mutated in Loop-tail, a well-established model for the study of neural tube defects (NTDs) in humans. This gene, called Vangl2, forms part of the non-canonical Frizzled/Dishevelled signaling pathway controlling morphogenetic processes essential for neurulation. She next identified mutations in human VANGL1 in a fraction of NTD patients. Her laboratory uses the tools of genetics, genomics and molecular biology in animal models and human cohorts to identify and characterize the genes predisposing to congenital malformations of the central nervous system and the associated axial skeletal structures. She is particularly interested in understanding the genetic and biological basis of two such malformations: NTDs and Chiari I malformation. These studies will help better understand the underlying pathological mechanisms and design novel preventive strategies and better counseling for couples at risk.

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