Personalized risk assessment for prevention and early detection of breast cancer: Integration and Implementation

Principal Investigator: Jacques Simard
Theme : Health
Competition : 2017 Large-Scale Applied Research Project Competition Genomics and Precision Health
Status : In progress
Start : Apr. 1, 2018
End: Mar. 31, 2022
Budget : $15,475,000.00



Breast cancer is the most common cancer in women in Canada and the second-leading cause of cancer death. Women face a one-in-eight chance of developing cancer in their lifetime. Current recommendations are that all women aged 50-74 have a screening mammogram every two-to-three years. Screening instead according to risk, through a combination of genomic profiling and other breast cancer risk factors, would enhance the benefits and reduce the risks of screening.

 

The evidence generated by this research project will support the transition from population-based to risk-based screening. It will also improve counseling for women with a family history of breast cancer who are seen in cancer genetic clinics. This improved approach to screening will enable earlier detection and treatment of breast cancer, saving lives and bringing health and socio-economic benefits.

 

The research team, led by Drs. Jacques Simard of Université Laval and Anna Maria Chiarelli of the University of Toronto, will study large cohorts of women using high throughput genomic technologies, together with statistical and epidemiological methods, to develop and validate a multi-gene panel test based on genetic variations associated with breast cancer. The team will also assess the acceptability and feasibility of using a new, comprehensive risk-prediction web-based tool and a genomic profiling test within the existing mammography screening system.

 

The results of this project will change breast-screening practice and ensure better use of human and financial resources, while reducing the burden of breast cancer on Canadian women.

 

Short version

This project will support a transformation in breast-cancer screening from a population-based approach to one based on risk. The research team will develop a multi-gene test based on genetic variations associated with breast cancer, to be used within existing mammography programs to ensure earlier detection and treatment of breast cancer and more efficient use of human and financial resources.

 

Lead Genome Centre: Génome Québec

Co-lead Genome Centre: Ontario Genomics

 

Co-project leader and User:

Anna Maria Chiarelli Cancer Care Ontario, University of Toronto

 

Co-applicants, Users and Collaborators:

Irene Andrulis University of Toronto
Antonis Antoniou University of Cambridge, Cambridge, United Kingdom
Jennifer Brooks University of Toronto
Jocelylne Chiquette Université Laval
Peter Devilee Leiden University Medical Center, Leiden, The Netherlands
Michel Dorval Université Laval
Arnaud Droit Université Laval
Douglas Easton University of Cambridge, Cambridge, United Kingdom
Andrea Eisen Sunnybrook Health Science Centre
Laurence Eloy Ministère de la Santé et des Services sociaux du Québec
David Goldgar University of Utah, Salt Lake City, United States
Yann Joly McGill University
Suzanne Kamel-Reid University of Toronto
Bartha Maria Knoppers McGill University
Jean-Yves Masson

Centre de recherche du CHU de Québec - Université Laval

Nicole Mittmann University of Toronto
Hermann Nabi Université Laval
Nora Pashayan University College London, London, United Kingdom
Rita Schmutzler University Hospital Cologne, Köln, Germany
Tracy Stockley University of Toronto
Sean Tavtigian University of Utah, Salt Lake City, United States
Haico van Attikum Leiden University Medical Center, Leiden, The Netherlands
Meghan Walker Cancer Care Ontario
Michael Wolfson University of Toronto
Linda Rabeneck Cancer Care Ontario
Nathalie Tremblay Quebec Breast Cancer Foundation
Jean Latreille Ministère de la Santé et des Services sociaux du Québec
Karen Malone Canadian Cancer Society
Nicole  Beben Canadian Partnership Against Cancer
Rami Rahal Canadian Partnership Against Cancer