Functional Genomics, Pharmacogenomics and Proteomics of the Immune Response in Health and Immune Related Disorders

Principal Investigator: Rafick-Pierre Sékaly
Theme : Health
Competition : Competition II
Status : Completed
Start : Feb. 1, 2003
End: Mar. 31, 2006
Budget : $14,214,373.00

The immune system is responsible for protecting us against disease. However, researchers are far from understanding how it operates at the molecular level. This project will focus on the contribution of genetic factors to immune-based diseases, such as: 1) endemic and incurable diseases with an emphasis on human immunodeficiency virus (HIV) and hepatitis C virus (HCV); 2) inflammatory diseases, e.g., rheumatoid arthritis; and 3) graft rejection of both solid organs and bone marrow. The researchers will analyze the genes involved in regulating the immune system, investigate the role of the recipient (or “host”) in explaining why immune-based treatments work in some people and not in others, and develop a computer simulation of the molecular mechanisms involved in immune-based diseases. Armed with this information, scientists would be in a much better position to develop appropriate therapies that will control or enhance the immune system. This project involves a consortium of scientists and private sector companies from both Canada and the United States, including researchers from Université de Montréal; the J.P. Robarts Institute, Mount Sinai Hospital, Hôpital Maisonneuve-Rosemont, McGill University, Jewish General Hospital, Biosystemix, Ellipsis, MDS Proteomics and Becton Dickinson.


Co-project leaders:

David Kelvin University Health Network
Katherine Siminovitch Ellipsis Biotherapeutics Corporation



Hui Fang Chen Hôpital Notre-Dame
Eleanor Fish University Health Network
Jack Gauldie McMaster University
John Hiscott Lady Davis Institute for Medical Research
Anthony Jevnikar London Health Sciences Centre
Claude Perreault Hôpital Maisonneuve-Rosemont
Robert Rottapel University of Toronto
Robert Singer Albert Einstein College of Medicine
Nahum Sonenberg McGill University
Jim Woodgett University Health Network
Robert Zhong London Health Sciences Centre