Benoit Coulombe

Affiliation : Université de Montréal
Organization : Institut de recherche cliniques de Montréal (IRCM)
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About Benoit Coulombe

Benoit Coulombe is the director of the Gene Transcription and Proteomics Laboratory at the Institut de recherches cliniques de Montréal and a Professor at the Université de Montréal. He was an undergraduate in Biochemistry and obtained his PhD in Molecular Biology at the Université de Montréal and undertook postdoctoral work at the University of Toronto under Jack Greenblatt and the Université Libre de Bruxelles (ULB) under Albert Goldbeter (School of Ilya Prigogine, Nobel Laureate in Chemistry). He moved at the Université de Sherbrooke as an Assistant Professor in 1993 where he attained the tenured rank of Full Professor and to the IRCM in Montréal in 2001. Over the past 15 years, he has explored the mechanisms by which regulated protein-protein, protein-DNA and protein-RNA interactions control the activity of RNA polymerase II during the transcription reaction. His “Promoter Wrapping Model” for transcriptional initiation by multi-subunit RNA polymerases has been included in a number of molecular biology textbooks. Recently, Benoit Coulombe described the development of a multi-step proteomics procedure used by his group to characterize the protein interaction network for the human RNA polymerase II transcription machinery and to identify many new proteins that regulate the function of RNA polymerase II and its accessory factors. Professor Coulombe is one of the leading scientists of the International Interactome Initiative (I3, pronounced I-cubed), an ambitious project aimed at developing enabling reagents and expertise for the systematic characterization of dynamic protein interaction networks in health and disease.

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