Jacques Drouin

Affiliation : Université de Montréal
Organization : Institut de recherche cliniques de Montréal (IRCM)
E-mail : Jacques.Drouin@ircm.qc.ca
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About Jacques Drouin

Jacques Drouin is Director of the Laboratory of Molecular Genetics at the Institut de recherches cliniques de Montréal. He is Professor of Biochemistry at Université de Montréal and a member of its Molecular Biology Program. He is a member of the Departments of Biochemistry, of Anatomy and Cell Biology, and of the Division of Experimental Medicine at McGill University.  

He is an elected member of the Academy of Sciences and Fellow of the Royal Society of Canada. He is also a member of the Canadian Academy of Health Sciences. He received a Honoris Causa Doctorate degree from Aix-Marseille Université.

His contributions center on the molecular basis of pituitary gland function, development and diseases, and encompass discovery of transcriptional regulators that control cell differentiation, organogenesis and are implicated in diseases.

These included discovery of 1) the Pitx subfamily of transcriptional regulators, 2) the Tbox factor Tpit, an essential regulator of pituitary cell fate that, when mutated, causes Isolated ACTH Deficiency, a fatal if untreated hormone deficiency and 3) the pioneer factor action of Pax7 to specify the intermediate pituitary fate and its mechanism of epigenetic action. Studies on transcriptional mechanisms of hormone action include repression by the glucocorticoid receptor (GR), extending from basic to genome-wide mechanisms and their implication for tumorigenesis and hormone resistance in Cushing’s disease. The latter studies include control of the cell cycle in normal development and disease, as well as the implementation of secretory capacity during cell differentiation. The group also investigated the role of Pitx genes in specification of hindlimb identity, in muscle development and in survival of dopaminergic neurons (Parkinson).

Ongoing competitions