Using whole genome sequencing to build a bridge between human exposure to antimicrobial resistant foodborne pathogens and the resulting burden of disease and associated healthcare costs

Principal Investigator: Paul J. Thomassin
Theme : Health
Competition : Genomics Integration Program - Human Health
Status : In progress
Start : July 1, 2021
End: June 30, 2023
Budget : $562,150.00

The problem to be investigated is the transmission of antimicrobial resistance (AMR) through the food supply chain. AMR is a national and international problem that has major negative health and economic implications. In 2018, resistant bacterial infections were responsible for over 14,000 deaths and had associated healthcare costs of $1.4 billion in Canada (CCA, 2019). To address the complexity of AMR from the food system, the Public Health Agency of Canada and its partners have developed an integrated assessment model (iAM.AMR) which models the potential human exposure to resistant bacteria from the food supply chain.  The current model uses phenotypic information to measure human exposure through the food supply chain.  This project address three issues (1) it will integrate whole genome sequencing information into the (iAM.AMR) model so that a better estimate of human exposure can be made (2) using the whole genome sequencing information, a bridge will be made between human exposure to AMR and the burden of disease that results from it, and (3) a preliminary estimate of the burden of disease will be made. 


Lead Genome Centre: Génome Québec


User :    

Richard J. Reid-Smith Public Health Agency of Canada