YCharOS – Antibody Characterization for Open Science – from viruses to human proteins

Principal Investigator: Peter S. McPherson
Theme : Health
Competition : Genome Canada competition - Genomic Applications Partnership Program (GAPP)
Status : In progress
Start : Oct. 1, 2021
End: Sept. 30, 2024
Budget : $4,000,000.00

Commercially available antibodies are key reagents in laboratory research with global sales estimated to be $2-3 billion USD. However, despite the size of the market and the importance of the product there is no independent, state-of-the-art quality assessment body for antibodies and as a result at least half of the antibodies on the market do not perform as required – leading to billions of dollars of wasted funding and a crisis of experimental reproducibility. YCharOS has developed a new characterization process that involves knockout cell lines that do not express the target protein.


With these cell lines as controls, and with inventive characterization steps, antibody performance against the cognate target protein can be quantified and compared in a range of commercially relevant applications. The long-term business model involves customers paying YCharOS to perform antibody studies on protein targets selected by one of the customers with a goal of attaining $9M in annual revenue by the end of the project and saving Canadian taxpayers $45M annually by enabling our scientists to order the right antibody for their experiments.


Lead Genome Centres: Ontario Genomics, Génome Québec

 User : 

Chetan Raina YCharOS Inc.