Major breakthrough in the quest for cancer vaccine

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Thursday December 6, 2018

Major breakthrough in the quest for cancer vaccine

The team of Dr. Claude Perreault at the Institute for Research in Immunology and Cancer (IRIC) at Université de Montréal has successfully shown how a vaccine could work to fight several types of cancers.

The team's work was published yesterday in Science Translational Medicine and  represents a major breakthrough. The team at IRIC looked for a solution in an unusual place: non-coding DNA sequences. Using mice injected with various types of cancer cells, the IRIC team was able to identify numerous antigens deriving from the non-coding portion of DNA, several of which were both specific to cancer cells and common to different types of cancer. This allowed the team to develop a vaccine based on leukemia cells containing some of the identified antigens, which was administered to the mice. The results were highly encouraging.

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